皇冠体育博彩的牙科研究
Cutting-edge science in the spirit of service.
Scholarly activity is an integral component of the mission of the 牙科学院 and 皇冠体育博彩大学, and we design all our research initiatives with the goal of better patient care. Extramural research funding totals nearly $1.5 million from federal agencies, foundations, corporations and other donors.
By conducting research focused on enhancing teaching, 改善社会, 发现新知识, the 牙科学院 has built a national and international reputation for science that serves.
学生研究机会
在我们教师的指导下, we strive to enhance student learning opportunities through the discovery of new knowledge.
- Students complete a research training course, “进行研究”, during their first semester of dental school. Completion of this course allows them to experience scientific inquiry in all its phases.
- All our first-year students participate in group research projects, which they present to the school’s faculty and alumni.
- Our students can collaborate with both basic science and clinical faculty members in conducting research. Students directly contribute to the production of peer-reviewed scientific publications as well as public presentation of research findings. 在过去, our students have addressed audiences as distinguished as the American Association for Dental 研究 和 International Association for Dental 研究.
- Pursuing such opportunities enhances the applications of our students to postdoctoral programs in dental specialties.
国际伙伴关系
The 皇冠体育博彩大学 牙科学院 has international research partnerships with the Department of Operative Dentistry in Nihon University in Tokyo, 日本, 和京都的Shofu公司, 日本. These academic and industrial fellowships have resulted in several research abstracts being presented at national and international research meeting and publications in peer-reviewed journals.
认可的研究
The 牙科学院 is well recognized in the research community for its excellence in dental materials research. 由赠款和伙伴关系支持, the research enterprise includes clinical trials on material and technique as well as laboratory investigations and collaborations with several 皇冠体育博彩大学 departments and institutions in 日本. 青年教师, 博士后研究人员, and graduate and undergraduate students take an active role in current research in dentistry, 如:
- adhesive dentistry and wear characteristics of resin composites and resin cements
- biology of lysophosphatidic acid in periodontal disease
- development of new dental products that combat recurrent decay
- auditory and oral tissue regeneration, caries research and oral inflammation
- 转化研究
- development of an inducible Dominant-Negative Retinoblastoma 1 (Rb1) mouse model
- role of miRNAs 和ir therapeutic potential in regenerating mammalian hair cells in treating hearing loss disease
- periostin’s role in dental tissue homeostasis
特色研究
Many of our faculty have secured extramural funding from public and private sources to include the National 研究院 of Health, 牙科工业和基金会.
教师-driven research at the 牙科学院 ranges from basic sciences to clinical investigations, including a variety of materials and techniques with translational potential into clinical applications to provide better care to our patients.
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重点研究领域
韦恩·W. Barkmeier, DDS, MS
特聘教授兼名誉院长
Dr. Barkmeier is extensively involved in biomaterials research and has conducted numerous clinical and laboratory evaluations on dental restorative materials. He has authored over 200 articles in professional journals and has lectured throughout the world on dental materials and restorative procedures. The focus of his research interest is in the areas of adhesive dentistry and wear characteristics of resin composites and resin cements. Current investigations involve shear bond strength and shear fatigue strength testing of current generation adhesive systems. These investigations also evaluate the surface morphological changes of mineralized tooth structures treated with the various adhesive bonding agents using scanning electron microscopy and non-contact profilometry. Wear studies have included simulated localized and generalized wear.
Current collaborations are with the Department of Physics at 皇冠体育博彩大学 in the area of atomic force microscopy and Nihon University 牙科学院 in Tokyo, 在日本的附着力和磨损方面.
罗瑟琳·塞鲁特斯博士
口腔生物学副教授
Dr. Cerutis’ laboratory works collaboratively with dentists in the 牙周病科 和 Department of Oral and Maxillofacial Surgery. The team’s long-term goal is to underst和 biology of lysophosphatidic acid (LPA) in periodontal disease. LPA is a pleiotropic small lipid that plays key roles in homeostasis and inflammation, and in many conditions where inflammation is the underlying process—such as atherosclerosis, 癌症和类风湿性关节炎. However, its role in periodontal disease is only now being determined. 多年来, many junior and senior dental students have contributed to the productivity of our laboratory research.
斯蒂芬·米. Gross博士
Associate Professor, Department of Chemistry
Dr. Gross与Dr. Latta have focused their research interests on the development of new dental materials that improve oral healthcare.
Caries initiation at the interface of dental materials and mineralized tooth structure continues to be a significant issue. Their research group mainly focuses on encapsulating bioactive therapeutic agents that can be incorporated into dental products that combat recurrent decay. Encapsulation of aqueous solutions of salts containing fluoride, calcium and phosphate ions provide a method for delivering remineralizing ions in their bioactive form. 这些微胶囊, 当配制成牙科材料时, allows for ion release by passive diffusion for an extended period of time in the proximity of the material-enamel interface.
研究的重点是离子释放率, enamel fluoride uptake 和 effect of microcapsule inclusion on material properties.
索尼娅·罗查-桑切斯博士
Associate Professor of Human Physiology and Biomedical 科学 of Oral Biology
研究助理院长
Dr. Rocha-Sanchez leads an active research program mentoring junior faculty, 博士后研究人员, graduate and undergraduate students in a variety of research projects. Current projects include auditory and oral tissue regeneration, 龋齿研究和口腔炎症.
Her lab’s past and current research has been funded by several federally and privately funded grants. Her current research projects involves the development of an inducible Dominant-Negative Retinoblastoma 1 (Rb1) mouse model, which offers potential research application on a broad variety of research areas.
Dr. Rocha-Sanchez is active in 转化研究 as well, discovering ways to develop innovative products derived from her findings. In fact, she founded and serves as vice president of F&S Medical Solutions LLC, a company focused on research and development of medical devices 和rapeutic interventions.
迈克尔D. 韦斯顿，硕士，博士
口腔生物学助理教授
Dr. Weston currently has research support from the Nebraska Tobacco Settlement Biomedical 研究 Development New Initiative Grant (LB692). The spontaneity of cochlear sensory hair cell (HC) regeneration has been lost in mammalian species which is why human hearing loss is irreversible following HC death. The project focuses on learning the role of miRNAs 和ir therapeutic potential in regenerating mammalian hair cells in the cochlea using mouse models to reprogram cell fates in the inner ear. The current objective to generate direct evidence that miRNA directed gene regulation promotes postnatal conversion of non-sensory cells into sensory cells.
The study should provide the hearing research field with a better understanding of the biological relevance of miRNAs in regenerating mammalian hair cells. 此外, it will add novel and medically relevant mechanistic insights in the control of gene expression by miRNAs, which may lead to novel ways of thinking about how, 当, and where to employ potential therapeutic RNAs to test their efficacy in treating hearing loss disease.
Dr. Weston is also supported from the CURAS 教师 研究 Fund. 在世界范围内, 80% of adults have some degree of periodontal disease and 13% have chronic severe disease that includes permanent tooth loss. The project focuses on studying periostin’s role in dental tissue homeostasis. Periostin, abundant in the periodontal ligament (PDL) of humans and mice, is an extracellular protein that communicates dynamic changes in mechanical loading to influence cell-matrix interactions and cell function. The award will provide funds to engage Creighton undergraduate students in tissue culture experiments to study cell signaling using fibroblasts isolated from the oral cavity of mice to better understand periodontal disease development and progression.
